Structure Without Alignment: How ESM-2 Folds a Single Sequence
ESMFold predicts atomic-level structure from a single sequence. No multiple sequence alignment, no database search, no Evoformer churning over homologs.
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2 articles tagged with #esm-2.
A Bioinformatician's Guide to Choosing Genomic Foundation Models
A practical guide to selecting genomic foundation models for bioinformatics tasks. Covers ESM-2, DNABERT-2, HyenaDNA, Nucleotide Transformer, scGPT, and Evo with scoped comparisons for DNA, proteins and single-cell analysis, with corrected references and clear distinctions between frozen representations and trained predictors.
