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UniProt // P04637 · TP53
(Homo sapiens)
PDB:1TUP ↗
+1aa
M
E
E
P
Q
S
D
P
S
V
E
P
P
L
S
Q
E
T
F
S
D
L
W
K
L
L
P
E
N
N
V
L
S
P
L
P
S
Q
A
M
D
D
L
M
L
S
P
D
D
I
+51aa
E
Q
W
F
T
E
D
P
G
P
D
E
A
P
R
M
P
E
A
A
P
P
V
A
P
A
P
A
A
P
T
P
A
A
P
A
P
A
P
S
W
P
L
S
S
S
V
P
S
Q
+101aa
K
T
Y
Q
G
S
Y
G
F
R
L
G
F
L
H
S
G
T
A
K
S
V
T
C
T
Y
S
P
A
L
N
K
M
F
C
Q
L
A
K
T
C
P
V
Q
L
W
V
D
S
T
+151aa
P
P
P
G
T
R
V
R
A
M
A
I
Y
K
Q
S
Q
H
M
T
E
V
V
R
R
C
P
H
H
E
R
C
S
D
S
D
G
L
A
P
P
Q
H
L
I
R
V
E
G
N
+201aa
L
R
V
E
Y
L
D
D
R
N
T
F
R
H
S
V
V
V
P
Y
E
P
P
E
V
G
S
D
C
T
T
I
H
Y
N
Y
M
C
N
S
S
C
M
G
G
M
N
R
R
P
+251aa
I
L
T
I
I
T
L
E
D
S
S
G
N
L
L
G
R
N
S
F
E
V
R
V
C
A
C
P
G
R
D
R
R
T
E
E
E
N
L
R
K
K
G
E
P
H
H
E
L
P
+301aa
P
G
S
T
K
R
A
L
P
N
N
T
S
S
S
P
Q
P
K
K
K
P
L
D
G
E
Y
F
T
L
Q
I
R
G
R
E
R
F
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M
F
R
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L
N
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A
L
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L
+351aa
K
D
A
Q
A
G
K
E
P
G
G
S
R
A
H
S
S
H
L
K
S
K
K
G
Q
S
T
S
R
H
K
K
L
M
F
K
T
E
G
P
D
S
D
///
+1aa
M
E
E
P
Q
S
D
P
S
V
E
P
P
L
S
Q
E
T
F
S
D
L
W
K
L
L
P
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N
N
V
L
S
P
L
P
S
Q
A
M
D
D
L
M
L
S
P
D
D
I
+51aa
E
Q
W
F
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P
G
P
D
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A
P
R
M
P
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A
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A
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A
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W
P
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S
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S
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+101aa
K
T
Y
Q
G
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Y
G
F
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L
G
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L
H
S
G
T
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K
S
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L
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K
M
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L
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+151aa
P
P
P
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T
R
V
R
A
M
A
I
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K
Q
S
Q
H
M
T
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H
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C
S
D
S
D
G
L
A
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P
Q
H
L
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R
V
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N
+201aa
L
R
V
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Y
L
D
D
R
N
T
F
R
H
S
V
V
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P
Y
E
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C
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H
Y
N
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M
C
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S
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C
M
G
G
M
N
R
R
P
+251aa
I
L
T
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L
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D
S
S
G
N
L
L
G
R
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A
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R
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T
E
E
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N
L
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K
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H
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+301aa
P
G
S
T
K
R
A
L
P
N
N
T
S
S
S
P
Q
P
K
K
K
P
L
D
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Y
F
T
L
Q
I
R
G
R
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R
F
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M
F
R
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L
N
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A
L
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L
+351aa
K
D
A
Q
A
G
K
E
P
G
G
S
R
A
H
S
S
H
L
K
S
K
K
G
Q
S
T
S
R
H
K
K
L
M
F
K
T
E
G
P
D
S
D
///
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